Set in late 1985 and early 1986, as the first wave of the AIDS epidemic in America is escalating and Ronald Reagan has been elected to a second term in the White House, the lives of disparate characters intersect, intertwine, collide and are blown apart during a time of heartbreak, reaction and transformation. Both parts, "Millenium Approaches" and "Perestroika" will be presented in rep.

This new production opened at the National Theatre in London in May 2017. The original production of "Angels in America" appeared on Broadway in 1993.